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Symbol
Name
ID 		Nhlh2
nescient helix loop helix 2
MGI:97324
Phenotype annotations related to reproductive system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Female hypogonadism
Hypogonadotropic hypogonadism
Male hypogonadism
Micropenis
Decreased testicular size
Cryptorchidism
Hypoplasia of the ovary
Hypoplasia of the uterus
Primary amenorrhea
Secondary amenorrhea
Increased female libido
Azoospermia
Non-obstructive azoospermia
Impotence
Disease(s) Associated with NHLH2
hypogonadotropic hypogonadism

Mouse Phenotypes
reproductive system phenotype
azoospermia
decreased male germ cell number
abnormal anogenital distance
small male preputial gland
abnormal seminal vesicle morphology
absent seminal vesicle
abnormal ovary morphology
absent corpus luteum
impaired ovarian folliculogenesis
small ovary
absent ovary
abnormal testis morphology
small seminiferous tubules
seminiferous tubule degeneration
decreased Leydig cell number
small testis
absent testes
bilateral cryptorchism
early reproductive senescence
small penis
abnormal uterus morphology
decreased uterus weight
small uterus
abnormal spermatogenesis
abnormal epididymis morphology
small epididymis
absent epididymis
abnormal vas deferens morphology
small gonad
delayed vaginal opening
decreased superovulation rate
abnormal estrous cycle
prolonged diestrus
short estrus
prolonged proestrus
female infertility
reduced female fertility
decreased litter size
male infertility
Availability Mouse Genotype
Nhlh2em1(IMPC)Mbp/Nhlh2em1(IMPC)Mbp
Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Nhlh2tm1Irk/Nhlh2tm1Irk
Nhlh2tm1Thbr/Nhlh2tm1Thbr
Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Pomc-EGFP)1Low/0
Tg(Pomc1-cre)16Lowl/0  (conditional)		 *
Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Agrp-cre)1Gsb/0  (conditional)		 *
Kiss1tm1.1(cre)Uboe/Kiss1+
Nhlh2tm2Thbr/Nhlh2tm2Thbr  (conditional)		 *
Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(CMV-cre)1Cgn/0  (conditional)
Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Gnrh1-cre)1Dlc/0
Tg(Pomc-EGFP)1Low/0  (conditional)		 *
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory